Dependencies between stimuli and spatially independent fMRI sources: Towards brain correlates of natural stimuli

Reference:

Jarkko Ylipaavalniemi, Eerika Savia, Sanna Malinen, Riitta Hari, Ricardo Vigário, and Samuel Kaski. Dependencies between stimuli and spatially independent fMRI sources: Towards brain correlates of natural stimuli. NeuroImage, 48(1):176–185, October 2009.

Abstract:

Natural stimuli are increasingly used in functional magnetic resonance imaging (fMRI) studies to imitate real-life situations. Consequently, challenges are created for novel analysis methods, including new machine learning tools. With natural stimuli it is no longer feasible to assume single features of the experimental design alone to account for the brain activity. Instead, relevant combinations of rich-enough stimulus features could explain the more complex activation patterns.

We propose a novel two-step approach, where independent component analysis is first used to identify spatially independent brain processes, which we refer to as emphfunctional patterns. As the second step, temporal dependencies between stimuli and functional patterns are detected using canonical correlation analysis. Our proposed method looks for combinations of stimulus features and the corresponding combinations of functional patterns.

This two-step approach was used to analyze measurements from a fMRI study during multi-modal stimulation. The detected complex activation patterns were explained as resulting from interactions of multiple brain processes. Our approach seems promising for analysis of data from studies with natural stimuli.

Keywords:

independent component analysis, canonical component analysis, functional magnetic resonance imaging

Suggested BibTeX entry:

@article{JYlipaavalniemi-2009-NIMG,
    author = {Jarkko Ylipaavalniemi and Eerika Savia and Sanna Malinen and Riitta Hari and Ricardo Vig\'{a}rio and Samuel Kaski},
    journal = {NeuroImage},
    month = {October},
    number = {1},
    pages = {176--185},
    title = {{D}ependencies between stimuli and spatially independent f{MRI} sources: {T}owards brain correlates of natural stimuli},
    volume = {48},
    year = {2009},
}